Human Nrf2 (NFE2L2) activation kit by CRISPRa

CAT#: GA103187

NFE2L2 CRISPRa kit - CRISPR gene activation of human nuclear factor, erythroid 2 like 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NFE2L2
• Locus ID: 4780
• Kit Components:

  GA103187G1, Nrf2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103187G2, Nrf2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103187G3, Nrf2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145412, NM_001145413, NM_001313900, NM_001313901, NM_001313902, NM_001313903, NM_001313904, NM_006164
• Synonyms: NRF2
• Summary: 'This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]'