Human NMBR activation kit by CRISPRa

CAT#: GA103221

NMBR CRISPRa kit - CRISPR gene activation of human neuromedin B receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NMBR
• Locus ID: 4829
• Kit Components:

  GA103221G1, NMBR gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103221G2, NMBR gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103221G3, NMBR gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001324307, NM_001324308, NM_002511
• Synonyms: BB1; BB1R; NMB-R
• Summary: 'This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]'