Human CNOT2 activation kit by CRISPRa

CAT#: GA103235

CNOT2 CRISPRa kit - CRISPR gene activation of human CCR4-NOT transcription complex subunit 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CNOT2
• Locus ID: 4848
• Kit Components:

  GA103235G1, CNOT2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103235G2, CNOT2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103235G3, CNOT2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199302, NM_001199303, NM_014515, NR_037615
• Synonyms: CDC36; HSPC131; NOT2; NOT2H
• Summary: 'This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]'