Human NOTCH3 activation kit by CRISPRa

CAT#: GA103241

NOTCH3 CRISPRa kit - CRISPR gene activation of human notch receptor 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NOTCH3
• Locus ID: 4854
• Kit Components:

  GA103241G1, NOTCH3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103241G2, NOTCH3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103241G3, NOTCH3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000435
• Synonyms: CADASIL; CADASIL1; CASIL; IMF2; LMNS
• Summary: 'This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]'