Human Nucleoside phosphorylase (PNP) activation kit by CRISPRa

CAT#: GA103246

PNP CRISPRa kit - CRISPR gene activation of human purine nucleoside phosphorylase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PNP
• Locus ID: 4860
• Kit Components:

  GA103246G1, Nucleoside phosphorylase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103246G2, Nucleoside phosphorylase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103246G3, Nucleoside phosphorylase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000270
• Synonyms: NP; PRO1837; PUNP
• Summary: 'This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Jul 2008]'