Human Natriuretic Peptide Receptor B (NPR2) activation kit by CRISPRa

CAT#: GA103259

NPR2 CRISPRa kit - CRISPR gene activation of human natriuretic peptide receptor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NPR2
• Locus ID: 4882
• Kit Components:

  GA103259G1, Natriuretic Peptide Receptor B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103259G2, Natriuretic Peptide Receptor B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103259G3, Natriuretic Peptide Receptor B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000907, NM_003995
• Synonyms: AMDM; ANPRB; GUC2B; GUCY2B; NPRB; NPRBi
• Summary: 'This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]'