Human NrCAM activation kit by CRISPRa

CAT#: GA103269

NRCAM CRISPRa kit - CRISPR gene activation of human neuronal cell adhesion molecule

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NRCAM
• Locus ID: 4897
• Kit Components:

  GA103269G1, NRCAM gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103269G2, NRCAM gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103269G3, NRCAM gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001037132, NM_001037133, NM_001193582, NM_001193583, NM_001193584, NM_005010
• Synonyms: KIAA0343; MGC138845; MGC138846
• Summary: 'Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]'