Human TrkA (NTRK1) activation kit by CRISPRa

CAT#: GA103281

NTRK1 CRISPRa kit - CRISPR gene activation of human neurotrophic receptor tyrosine kinase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NTRK1
• Locus ID: 4914
• Kit Components:

  GA103281G1, TrkA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103281G2, TrkA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103281G3, TrkA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001007792, NM_001012331, NM_002529
• Synonyms: MTC; p140-TrkA; TRK; Trk-A; TRK1; TRKA
• Summary: 'This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]'