Human ROR1 activation kit by CRISPRa

CAT#: GA103285

ROR1 CRISPRa kit - CRISPR gene activation of human receptor tyrosine kinase like orphan receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ROR1
• Locus ID: 4919
• Kit Components:

  GA103285G1, ROR1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103285G2, ROR1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103285G3, ROR1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001083592, NM_005012
• Synonyms: dJ537F10.1; NTRKR1
• Summary: 'This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]'