Human ROR2 activation kit by CRISPRa

CAT#: GA103286

ROR2 CRISPRa kit - CRISPR gene activation of human receptor tyrosine kinase like orphan receptor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ROR2
• Locus ID: 4920
• Kit Components:

  GA103286G1, ROR2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103286G2, ROR2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103286G3, ROR2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001318204, NM_004560
• Synonyms: BDB; BDB1; NTRKR2
• Summary: 'The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]'