Human NuMA (NUMA1) activation kit by CRISPRa

CAT#: GA103292

NUMA1 CRISPRa kit - CRISPR gene activation of human nuclear mitotic apparatus protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NUMA1
• Locus ID: 4926
• Kit Components:

  GA103292G1, NuMA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103292G2, NuMA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103292G3, NuMA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286561, NM_006185, NR_104476
• Synonyms: NMP-22; NUMA
• Summary: 'This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]'