Human OAS1 activation kit by CRISPRa

CAT#: GA103298

OAS1 CRISPRa kit - CRISPR gene activation of human 2'-5'-oligoadenylate synthetase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OAS1
• Locus ID: 4938
• Kit Components:

  GA103298G1, OAS1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103298G2, OAS1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103298G3, OAS1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001032409, NM_001320151, NM_002534, NM_016816
• Synonyms: IFI-4; OIAS; OIASI
• Summary: 'This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, Feb 2016]'