Human OAS2 activation kit by CRISPRa

CAT#: GA103299

OAS2 CRISPRa kit - CRISPR gene activation of human 2'-5'-oligoadenylate synthetase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OAS2
• Locus ID: 4939
• Kit Components:

  GA103299G1, OAS2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103299G2, OAS2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103299G3, OAS2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001032731, NM_002535, NM_016817
• Synonyms: MGC78578
• Summary: 'This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]'