Human INPP5F (OCRL) activation kit by CRISPRa

CAT#: GA103307

OCRL CRISPRa kit - CRISPR gene activation of human OCRL inositol polyphosphate-5-phosphatase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OCRL
• Locus ID: 4952
• Kit Components:

  GA103307G1, INPP5F gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103307G2, INPP5F gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103307G3, INPP5F gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000276, NM_001318784, NM_001587
• Synonyms: INPP5F; LOCR; NPHL2; OCRL-1; OCRL1
• Summary: 'This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]'