Human OGG1 activation kit by CRISPRa

CAT#: GA103313

OGG1 CRISPRa kit - CRISPR gene activation of human 8-oxoguanine DNA glycosylase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OGG1
• Locus ID: 4968
• Kit Components:

  GA103313G1, OGG1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103313G2, OGG1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103313G3, OGG1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002542, NM_016819, NM_016820, NM_016821, NM_016826, NM_016827, NM_016828, NM_016829, NM_001354648, NM_001354649, NM_001354650, NM_001354651, NM_001354652, NR_148930, NR_148931, NR_148932
• Synonyms: HMMH; HOGG1; MUTM; OGH1
• Summary: 'This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]'