Human OPA1 activation kit by CRISPRa

CAT#: GA103318

OPA1 CRISPRa kit - CRISPR gene activation of human OPA1 mitochondrial dynamin like GTPase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OPA1
• Locus ID: 4976
• Kit Components:

  GA103318G1, OPA1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103318G2, OPA1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103318G3, OPA1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015560, NM_130831, NM_130832, NM_130833, NM_130834, NM_130835, NM_130836, NM_130837, NM_001354663, NM_001354664
• Synonyms: BERHS; largeG; MGM1; MTDPS14; NPG; NTG
• Summary: 'The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. [provided by RefSeq, Aug 2017]'