Human OPCML activation kit by CRISPRa

CAT#: GA103319

OPCML CRISPRa kit - CRISPR gene activation of human opioid binding protein/cell adhesion molecule like

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OPCML
• Locus ID: 4978
• Kit Components:

  GA103319G1, OPCML gRNA vector 1 in pCas-Guide-CRISPRa

  GA103319G2, OPCML gRNA vector 2 in pCas-Guide-CRISPRa

  GA103319G3, OPCML gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001012393, NM_001319103, NM_001319104, NM_001319105, NM_001319106, NM_002545
• Synonyms: IGLON1; OBCAM; OPCM
• Summary: This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]