Human Osteoprotegerin (TNFRSF11B) activation kit by CRISPRa

CAT#: GA103320

TNFRSF11B CRISPRa kit - CRISPR gene activation of human TNF receptor superfamily member 11b

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TNFRSF11B
• Locus ID: 4982
• Kit Components:

  GA103320G1, Osteoprotegerin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103320G2, Osteoprotegerin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103320G3, Osteoprotegerin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002546
• Synonyms: OCIF; OPG; TR1
• Summary: 'The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]'