Human OTX2 activation kit by CRISPRa

CAT#: GA103345

OTX2 CRISPRa kit - CRISPR gene activation of human orthodenticle homeobox 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OTX2
• Locus ID: 5015
• Kit Components:

  GA103345G1, OTX2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103345G2, OTX2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103345G3, OTX2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001270523, NM_001270524, NM_001270525, NM_021728, NM_172337, NR_073034, NR_073036
• Synonyms: CPHD6; MCOPS5
• Summary: 'This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012]'