Human P2RX7 activation kit by CRISPRa

CAT#: GA103356

P2RX7 CRISPRa kit - CRISPR gene activation of human purinergic receptor P2X 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: P2RX7
• Locus ID: 5027
• Kit Components:

  GA103356G1, P2RX7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103356G2, P2RX7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103356G3, P2RX7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002562, NM_177427, NR_033948, NR_033949, NR_033950, NR_033951, NR_033952, NR_033953, NR_033954, NR_033955, NR_033956
• Synonyms: P2X7
• Summary: 'The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]'