Human P2Y2 (P2RY2) activation kit by CRISPRa

CAT#: GA103358

P2RY2 CRISPRa kit - CRISPR gene activation of human purinergic receptor P2Y2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: P2RY2
• Locus ID: 5029
• Kit Components:

  GA103358G1, P2Y2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103358G2, P2Y2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103358G3, P2Y2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002564, NM_176071, NM_176072
• Synonyms: HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R
• Summary: 'The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]'