Human PAFAH1B3 activation kit by CRISPRa

CAT#: GA103372

PAFAH1B3 CRISPRa kit - CRISPR gene activation of human platelet activating factor acetylhydrolase 1b catalytic subunit 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PAFAH1B3
• Locus ID: 5050
• Kit Components:

  GA103372G1, PAFAH1B3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103372G2, PAFAH1B3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103372G3, PAFAH1B3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145939, NM_001145940, NM_002573
• Synonyms: PAFAHG
• Summary: 'This gene encodes an acetylhydrolase that catalyzes the removal of an acetyl group from the glycerol backbone of platelet-activating factor. The encoded enzyme is a subunit of the platelet-activating factor acetylhydrolase isoform 1B complex, which consists of the catalytic beta and gamma subunits and the regulatory alpha subunit. This complex functions in brain development. A translocation between this gene on chromosome 19 and the CDC-like kinase 2 gene on chromosome 1 has been observed, and was associated with cognitive disability, ataxia, and atrophy of the brain. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]'