Human PAK1 activation kit by CRISPRa

CAT#: GA103378

PAK1 CRISPRa kit - CRISPR gene activation of human p21 (RAC1) activated kinase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PAK1
• Locus ID: 5058
• Kit Components:

  GA103378G1, PAK1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103378G2, PAK1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103378G3, PAK1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001128620, NM_002576
• Synonyms: PAKalpha
• Summary: 'This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]'