Human PAK2 activation kit by CRISPRa

CAT#: GA103379

PAK2 CRISPRa kit - CRISPR gene activation of human p21 (RAC1) activated kinase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PAK2
• Locus ID: 5062
• Kit Components:

  GA103379G1, PAK2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103379G2, PAK2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103379G3, PAK2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002577
• Synonyms: PAK65; PAKgamma
• Summary: 'The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]'