Human Parkin (PARK2) activation kit by CRISPRa

CAT#: GA103386

PRKN CRISPRa kit - CRISPR gene activation of human parkin RBR E3 ubiquitin protein ligase

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Find the corresponding CRISPRi Inhibitor Kit

USD 1,290.00

2 Weeks*

Size
    • 1 kit

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Specifications

Product Data
Format 3gRNAs, 1 scramble ctrl and 1 enhancer vector
Symbol PRKN
Locus ID 5071
Kit Components

GA103386G1, Parkin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA103386G2, Parkin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA103386G3, Parkin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_004562, NM_013987, NM_013988
Synonyms AR-JP; LPRS2; PDJ; PRKN
Summary 'The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]'

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.