Human PARN activation kit by CRISPRa

CAT#: GA103387

PARN CRISPRa kit - CRISPR gene activation of human poly(A)-specific ribonuclease

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PARN
• Locus ID: 5073
• Kit Components:

  GA103387G1, PARN gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103387G2, PARN gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103387G3, PARN gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001134477, NM_001242992, NM_002582
• Synonyms: DAN; DKCB6; PFBMFT4
• Summary: 'The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]'