Human PAX3 activation kit by CRISPRa

CAT#: GA103391

PAX3 CRISPRa kit - CRISPR gene activation of human paired box 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PAX3
• Locus ID: 5077
• Kit Components:

  GA103391G1, PAX3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103391G2, PAX3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103391G3, PAX3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000438, NM_001127366, NM_013942, NM_181457, NM_181458, NM_181459, NM_181460, NM_181461
• Synonyms: CDHS; HUP2; WS1; WS3
• Summary: 'This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. [provided by RefSeq, Jul 2008]'