Human PBX1 activation kit by CRISPRa

CAT#: GA103399

PBX1 CRISPRa kit - CRISPR gene activation of human PBX homeobox 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PBX1
• Locus ID: 5087
• Kit Components:

  GA103399G1, PBX1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103399G2, PBX1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103399G3, PBX1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001204961, NM_001204963, NM_002585, NM_001353130, NM_001353131
• Synonyms: DKFZp686B09108; MGC126627
• Summary: 'This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]'