Human PCMT1 activation kit by CRISPRa

CAT#: GA103417

PCMT1 CRISPRa kit - CRISPR gene activation of human protein-L-isoaspartate (D-aspartate) O-methyltransferase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PCMT1
• Locus ID: 5110
• Kit Components:

  GA103417G1, PCMT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103417G2, PCMT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103417G3, PCMT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001252049, NM_001252050, NM_001252051, NM_001252052, NM_001252053, NM_005389, NM_001360452, NM_001360456
• Synonyms: PIMT
• Summary: 'This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]'