Human PCNA activation kit by CRISPRa

CAT#: GA103418

PCNA CRISPRa kit - CRISPR gene activation of human proliferating cell nuclear antigen

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PCNA
• Locus ID: 5111
• Kit Components:

  GA103418G1, PCNA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103418G2, PCNA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103418G3, PCNA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002592, NM_182649
• Synonyms: ATLD2
• Summary: 'The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]'