Human PDE3A activation kit by CRISPRa

CAT#: GA103436

PDE3A CRISPRa kit - CRISPR gene activation of human phosphodiesterase 3A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDE3A
• Locus ID: 5139
• Kit Components:

  GA103436G1, PDE3A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103436G2, PDE3A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103436G3, PDE3A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000921, NM_001244683
• Synonyms: CGI-PDE; CGI-PDE-A; CGI-PDE A
• Summary: 'This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]'