Human PDE4A activation kit by CRISPRa

CAT#: GA103438

PDE4A CRISPRa kit - CRISPR gene activation of human phosphodiesterase 4A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDE4A
• Locus ID: 5141
• Kit Components:

  GA103438G1, PDE4A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103438G2, PDE4A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103438G3, PDE4A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001111307, NM_001111308, NM_001111309, NM_001243121, NM_006202
• Synonyms: DPDE2; PDE4; PDE46
• Summary: 'The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]'