Human PDE8A activation kit by CRISPRa

CAT#: GA103448

PDE8A CRISPRa kit - CRISPR gene activation of human phosphodiesterase 8A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDE8A
• Locus ID: 5151
• Kit Components:

  GA103448G1, PDE8A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103448G2, PDE8A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103448G3, PDE8A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001243137, NM_002605, NM_173454, NM_173455, NM_173456, NM_173457
• Synonyms: HsT19550
• Summary: 'The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]'