Human PEX6 activation kit by CRISPRa

CAT#: GA103482

PEX6 CRISPRa kit - CRISPR gene activation of human peroxisomal biogenesis factor 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PEX6
• Locus ID: 5190
• Kit Components:

  GA103482G1, PEX6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103482G2, PEX6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103482G3, PEX6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000287, NM_001316313, NR_133009
• Synonyms: HMLR2; PAF-2; PAF2; PBD4A; PDB4B; PXAAA1
• Summary: 'This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) family of ATPases. This member is a predominantly cytoplasmic protein, which plays a direct role in peroxisomal protein import and is required for PTS1 (peroxisomal targeting signal 1, a C-terminal tripeptide of the sequence ser-lys-leu) receptor activity. Mutations in this gene cause peroxisome biogenesis disorders of complementation group 4 and complementation group 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]'