Human PFKM activation kit by CRISPRa

CAT#: GA103503

PFKM CRISPRa kit - CRISPR gene activation of human phosphofructokinase, muscle

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PFKM
• Locus ID: 5213
• Kit Components:

  GA103503G1, PFKM gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103503G2, PFKM gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103503G3, PFKM gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000289, NM_001166686, NM_001166687, NM_001166688, NM_001354735, NM_001354736, NM_001354737, NM_001354738, NM_001354739, NM_001354740, NM_001354741, NM_001354742, NM_001354743, NM_001354744, NM_001354745, NM_001354746, NM_001354747, NM_001354748, NR_148954, NR_148955, NR_148956, NR_148957, NR_148958, NR_148959, NM_001363619
• Synonyms: ATP-PFK; GSD7; PFK-1; PFK1; PFKA; PFKX; PPP1R122
• Summary: 'Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]'