Human PGM1 activation kit by CRISPRa

CAT#: GA103517

PGM1 CRISPRa kit - CRISPR gene activation of human phosphoglucomutase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PGM1
• Locus ID: 5236
• Kit Components:

  GA103517G1, PGM1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103517G2, PGM1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103517G3, PGM1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001172818, NM_001172819, NM_002633
• Synonyms: CDG1T; GSD14
• Summary: 'The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Mar 2010]'