Human PHYH activation kit by CRISPRa

CAT#: GA103533

PHYH CRISPRa kit - CRISPR gene activation of human phytanoyl-CoA 2-hydroxylase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PHYH
• Locus ID: 5264
• Kit Components:

  GA103533G1, PHYH gRNA vector 1 in pCas-Guide-CRISPRa

  GA103533G2, PHYH gRNA vector 2 in pCas-Guide-CRISPRa

  GA103533G3, PHYH gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001037537, NM_001323080, NM_001323082, NM_001323083, NM_001323084, NM_006214
• Synonyms: LN1; LNAP1; PAHX; PHYH1; RD
• Summary: This gene is a member of the PhyH family and encodes a peroxisomal protein that is involved in the alpha-oxidation of 3-methyl branched fatty acids. Specifically, this protein converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. Mutations in this gene have been associated with Refsum disease (RD) and deficient protein activity has been associated with Zellweger syndrome and rhizomelic chondrodysplasia punctata. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]