Human PI 3 Kinase catalytic subunit alpha (PIK3CA) activation kit by CRISPRa

CAT#: GA103555

PIK3CA CRISPRa kit - CRISPR gene activation of human phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PIK3CA
• Locus ID: 5290
• Kit Components:

  GA103555G1, PI 3 Kinase catalytic subunit alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103555G2, PI 3 Kinase catalytic subunit alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103555G3, PI 3 Kinase catalytic subunit alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006218
• Synonyms: CLOVE; CWS5; MCAP; MCM; MCMTC; p110-alpha; PI3K; PI3K-alpha
• Summary: 'Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016]'