Human Phospholipase A2 IIA (PLA2G2A) activation kit by CRISPRa

CAT#: GA103581

PLA2G2A CRISPRa kit - CRISPR gene activation of human phospholipase A2 group IIA

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PLA2G2A
• Locus ID: 5320
• Kit Components:

  GA103581G1, Phospholipase A2 IIA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103581G2, Phospholipase A2 IIA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103581G3, Phospholipase A2 IIA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000300, NM_001161727, NM_001161728, NM_001161729
• Synonyms: MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2
• Summary: 'The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]'