Human uPA (PLAU) activation kit by CRISPRa

CAT#: GA103588

PLAU CRISPRa kit - CRISPR gene activation of human plasminogen activator, urokinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PLAU
• Locus ID: 5328
• Kit Components:

  GA103588G1, uPA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103588G2, uPA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103588G3, uPA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145031, NM_001319191, NM_002658
• Synonyms: ATF; BDPLT5; QPD; u-PA; UPA; URK
• Summary: 'This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]'