Human PLCD1 activation kit by CRISPRa

CAT#: GA103593

PLCD1 CRISPRa kit - CRISPR gene activation of human phospholipase C delta 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PLCD1
• Locus ID: 5333
• Kit Components:

  GA103593G1, PLCD1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103593G2, PLCD1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103593G3, PLCD1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001130964, NM_006225, NR_024071
• Synonyms: NDNC3; PLC-III
• Summary: 'This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]'