Human PLCG 2 (PLCG2) activation kit by CRISPRa

CAT#: GA103596

PLCG2 CRISPRa kit - CRISPR gene activation of human phospholipase C gamma 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PLCG2
• Locus ID: 5336
• Kit Components:

  GA103596G1, PLCG 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103596G2, PLCG 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103596G3, PLCG 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002661
• Synonyms: APLAID; FCAS3; PLC-gamma-2; PLC-IV
• Summary: 'The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]'