Human Noxa (PMAIP1) activation kit by CRISPRa

CAT#: GA103623

PMAIP1 CRISPRa kit - CRISPR gene activation of human phorbol-12-myristate-13-acetate-induced protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PMAIP1
• Locus ID: 5366
• Kit Components:

  GA103623G1, Noxa gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103623G2, Noxa gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103623G3, Noxa gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_021127
• Synonyms: APR; NOXA
• Summary: 'This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis. In response to death-inducing stimuli, BH3-only members inhibit the anti-apoptotic BCL-2 family members, which under steady-state conditions keep the multi-BH domain proteins BAX and BAK, in an inactive state. [provided by RefSeq, Aug 2020]'