Human Nociceptin (PNOC) activation kit by CRISPRa

CAT#: GA103625

PNOC CRISPRa kit - CRISPR gene activation of human prepronociceptin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PNOC
• Locus ID: 5368
• Kit Components:

  GA103625G1, Nociceptin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103625G2, Nociceptin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103625G3, Nociceptin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001284244, NM_006228
• Synonyms: PPNOC
• Summary: 'This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]'