Human Pancreatic Lipase (PNLIP) activation kit by CRISPRa

CAT#: GA103636

PNLIP CRISPRa kit - CRISPR gene activation of human pancreatic lipase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PNLIP
• Locus ID: 5406
• Kit Components:

  GA103636G1, Pancreatic Lipase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103636G2, Pancreatic Lipase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103636G3, Pancreatic Lipase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000936
• Synonyms: PL; PNLIPD; PTL
• Summary: 'This gene encodes a member of the lipase family of proteins. The encoded enzyme is secreted by the pancreas and hydrolyzes triglycerides in the small intestine, and is essential for the efficient digestion of dietary fats. Inhibition of the encoded enzyme may prevent high-fat diet-induced obesity in mice and result in weight loss in human patients with obesity. Mutations in this gene cause congenital pancreatic lipase deficiency, a rare disorder characterized by steatorrhea. [provided by RefSeq, Jul 2016]'