Human PON1 activation kit by CRISPRa

CAT#: GA103667

PON1 CRISPRa kit - CRISPR gene activation of human paraoxonase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PON1
• Locus ID: 5444
• Kit Components:

  GA103667G1, PON1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103667G2, PON1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103667G3, PON1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000446
• Synonyms: ESA; MVCD5; PON
• Summary: 'This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7. [provided by RefSeq, Aug 2017]'