Human PPAR alpha (PPARA) activation kit by CRISPRa

CAT#: GA103686

PPARA CRISPRa kit - CRISPR gene activation of human peroxisome proliferator activated receptor alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PPARA
• Locus ID: 5465
• Kit Components:

  GA103686G1, PPAR alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103686G2, PPAR alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103686G3, PPAR alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001001928, NM_001001929, NM_001001930, NM_005036, NM_032644, NM_001362872, NM_001362873
• Synonyms: hPPAR; NR1C1; PPAR; PPARalpha
• Summary: 'Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]'