Human PPT1 activation kit by CRISPRa

CAT#: GA103737

PPT1 CRISPRa kit - CRISPR gene activation of human palmitoyl-protein thioesterase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PPT1
• Locus ID: 5538
• Kit Components:

  GA103737G1, PPT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103737G2, PPT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103737G3, PPT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000310, NM_001142604, NM_001363695
• Synonyms: CLN1; INCL; PPT
• Summary: 'The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2008]'