Human Major Basic Protein (PRG2) activation kit by CRISPRa

CAT#: GA103749

PRG2 CRISPRa kit - CRISPR gene activation of human proteoglycan 2, pro eosinophil major basic protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PRG2
• Locus ID: 5553
• Kit Components:

  GA103749G1, Major Basic Protein gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103749G2, Major Basic Protein gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103749G3, Major Basic Protein gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001243245, NM_001302926, NM_001302927, NM_002728
• Synonyms: BMPG; MBP; MBP1
• Summary: 'The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]'