Human MEK5 (MAP2K5) activation kit by CRISPRa

CAT#: GA103797

MAP2K5 CRISPRa kit - CRISPR gene activation of human mitogen-activated protein kinase kinase 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MAP2K5
• Locus ID: 5607
• Kit Components:

  GA103797G1, MEK5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103797G2, MEK5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103797G3, MEK5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001206804, NM_002757, NM_145160, NM_145161, NM_145162
• Synonyms: HsT17454; MAPKK5; MEK5; PRKMK5
• Summary: 'The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]'